LabKey Vision 2018

2017 was a year of many milestones for the LabKey team. Our newest product, LabKey Biologics, launched in April and has been implemented at four leading pharma and biotech companies, we redesigned the LabKey Server user interface, and we took our compliance functionality to the next level with the introduction of compliant hosting and a suite of new features to support teams working within HIPAA, FISMA and CFR Part 11 compliant environments. LabKey is excited about what the next year has in-store and we want to share our vision for 2018 with the growing LabKey community.

LabKey Server Premium Functionality: R Studio, PHI/PII Handling, Clinical Ontologies

Reinvesting Premium Dollars into Premium Functionality

Each year, LabKey invests in a number of development projects that premium subscribers have shared as key priorities. In 2018, we plan to dedicate development time to a variety of key areas including:

  • Helping secure access to protected data with added support for PHI/PII handling
  • Opening the power of R to more users in a secure manner by introducing sandboxing of R code execution
  • Increasing the reliability and reproducibility of results via versioning of R engines and packages within RStudio configurations
  • Streamlining data integration and enabling rich querying by adding support for clinical ontologies and controlled vocabularies
  • Automating and expanding data acquisition options through pipeline file watchers and integration with cloud storage providers

Curious what new  functionality was introduced in 2017? Read our “What’s New” updates >

Biologics R&D Roadmap: Experiment Grouping of Samples, Assay Data, Lineage Delivering on the Biologics Roadmap

The LabKey Biologics team, in partnership with our product advisory council, has developed an aggressive roadmap for continued development of this flexible system for biologic discovery and development. In 2018, the team will be focusing much of their efforts on:

  • Simplifying access to all relevant experiment data by enabling the grouping of samples, assay data, and notes by experiment
  • Helping teams better understand their data by expanding reporting and visualization capabilities
  • Making it easier for users to standardize and track the creation of media batches through usability improvements to the application’s media registration tools

Interested in learning more about LabKey Biologics? Watch our “Quick Look” video series >

LabKey Software Infrustructure: Java 9, Javascript Shared ComponentsStrengthening our Core Technology Infrastructure

In order to support our ongoing commitment to providing reliable software solutions, each year we dedicate resources to evolving our technology infrastructure to ensure its on-going stability. This year, we are largely focused on enhancements that will improve efficiency for both internal and external developers working with LabKey Server. Our key priorities include the development of a method for sharing JavaScript components between modules, fully supporting Java 9, and maintaining full compatibility with new versions of third-party components.

LabKey Server UX Refinements: New User Experience, Hosted Data Management Solutions, Compliant HostingRefining the LabKey Server User Interface, According to User Feedback

We have heard from new users of LabKey Server that the current experience makes it difficult to get started using the platform. In order to make sure new users can be successful using LabKey Server from the get go, our UX team will be working with new users over the next few months to understand how we can improve our user interface and the tools we provide. In addition, we will be continuing to expand our our hosted solutions in 2018 to make it easier for organizations to adopt and support LabKey Server.

Want to learn more about the recent LabKey Server UI changes? Check out our “New LabKey Server UI” blog series >

In addition to strengthening our solutions this year, we want to continue to strengthen our relationships with you, the LabKey community. We hope that you will join us in this journey toward creating robust and powerful tools for accelerating research. A few ways that you can get involved this year include:

Providing Feedback on the New UI

As teams upgrade to LabKey Server version 17.3 and later, we encourage you to provide feedback about the new UI through the “Give Feedback” form that can be accessed in your LabKey Server account menu. This feedback is reviewed, prioritized, and used directly to help us make decisions about refinements to the LabKey Server UI.

Participating in a New User Walk-Through

Are you new to using LabKey Server? We want to hear about your experience and how we can improve! LabKey User Experience Manager, Jessi Murray, is looking for new users who would be willing to discuss their experience getting started with LabKey Server and how it could be improved.

Email Jessi Murray at jessim@labkey.com for more information!

Attending the LabKey User Conference

The LabKey User Conference is an opportunity for users to gather together and share about how they are using and extending the LabKey platform and solutions. Attendees also participate in round table discussions and work sessions with the LabKey developers where they can explore current challenges and shared feedback directly with the LabKey team.

Interested in speaking at the LabKey User Conference? Email conference manager, Kelsey Gibson at kelseyg@labkey.com for more information!

LabKey Biologics: A Year in Review

As this year comes to a close, we wanted to take a few minutes to reflect on the year and thank you for joining us on the LabKey Biologics journey. It has been an amazing year and we couldn’t be more excited about what’s coming in 2018!

Launching LabKey Biologics

One of the key parts of developing this application has been the engagement from our LabKey Biologics Product Advisory Council. Since its inception, we’ve been meeting monthly with eight different biotech, pharma, and academic institutions to get feedback. They’ve let us know what we’re doing right (and wrong) and have been invaluable in guiding the product development.

After working with the Product Advisory Council and our initial collaborator, Just Biotherapeutics, for 18 months, we officially launched LabKey Biologics in March. This first version focused on:

Just Biotherapeutics has been rolling out LabKey Biologics and has registered hundreds of biological entities, used workflow management to request thousands of assays, and uploaded analytical data for tens of thousands of samples. Several other members of our advisory board have also become clients and are in the process of implementing LabKey Biologics at their organizations.

Following the release of LabKey Biologics, we had the chance to talk with hundreds of individuals about the new product at PEGS Boston and Bio-IT (we’ll be at both shows again in 2018). Gathering feedback from folks in different roles throughout the industry, active users, and advisory board members has helped us improve the product and plan for future enhancements.

Since we launched in March, we’ve worked on many different improvements to the product. Some of the larger efforts include:

  • Additional Methods to Upload Assay Data
  • Defining the Lineage of a Sample, from Bioreactor Run to Purified Antibody
  • Media Registration – More Options and Ease of Use
  • Updates to the User Interface

What’s Next

As we look to 2018, we are excited to continue expanding the functionality of LabKey Biologics. We’ve got big plans for the next 12 months, including:

  • Defining Experiments
  • Building Analyses and Reports
  • Mapping and Characterizing Post-Translational Modifications
  • Improvements to Bulk Import of Entity Registry, Assay, and Media Data
  • Integrating Custom Assay Definitions with LabKey Biologics

Product Feedback

We’re always interested in feedback! We’d love to connect with each of you in the new year, and have a conversation (or several) to hear about your needs and thoughts on the product’s direction. If you’d like to learn more about LabKey Biologics, we’re hosting a free Intro to Biologics webinar on January 9.

Don’t hesitate to get in touch with us – and best wishes to you in the New Year!

LabKey Biologics Team

Ryan Luce, Product Manager
Email: ryanl@labkey.com

Kevin Krouse, Lead Software Engineer
Email: kevink@labkey.com

Before & After: A Side-by-Side Look at the New LabKey Server UI

The upcoming redesign of the LabKey Server user interface includes a variety of updates; some of which are focused on look and feel, some on interface behavior, and some technical stability. All of these changes and enhancements were carefully selected because of the contribution they will make to the overall usability of the platform. Prior to the release of the new UI as part of LabKey Server v17.3, we wanted to give users a side-by-side look at some of the key updates and how they will differ from the current UI.[vc_row gap=”30″]

Landing Page

Many of the key changes to the LabKey Server UI can be seen upon your arrival on the LabKey Server landing pages. The new interface features an updated header style with a more compact navigation and reorganized menus, the addition of a new “frameless” webpart style, and updated logic that will hide the tab bar on home projects if there is only one tab present.[asvc_before_after before_image=”76688″ after_image=”76792″][vc_row gap=”30″]

Page Administration

In order to reduce the visual noise and present a cleaner UI for administrators, we have introduced a “page admin mode.” Options like “add web part” and tab editing will no longer be presented at all times and will instead only be visible when the user turns on page admin mode. Page admin mode can be easily turned on when edits to a page are needed and turned off when edits are complete.[asvc_before_after before_image=”76691″ after_image=”76793″][vc_row gap=”30″]

Data Grids

Several changes have been made to the LabKey data grids in order to declutter the grid navigation and increase readability. The most notable changes include the introduction of a more icon-driven button bar with tooltips for each action available on hover, a simplified “edit” link presentation, and the addition of row highlighting. [asvc_before_after before_image=”76684″ after_image=”76794″][vc_row gap=”30″]

Grid Customization

The customizing grids of data has been simplified in the new LabKey Server UI. With this update, filters and sorts added to a grid are always carried with view and no longer require an opt-in. Additionally, filters can be quickly edited using one click to reopen the filter pane or removed with by clicking the newly added [x] icon next to each filter definition.[asvc_before_after before_image=”76682″ after_image=”76795″][vc_row gap=”30″]

Menus

Updates to the LabKey Server menu are both visual and technical in nature. A major shift included as part of the redesign is the transition to menus written in Bootstrap instead of Ext, that take advantage of Bootstrap’s consistent styling and built-in behavior for multiple form factors. Sub-menu behavior has also been updated so that sub-menus now replace the menu content (with a back to menu option) instead of appearing next to the primary menu. This change makes the navigating to 2nd level sub menus a much cleaner experience, as users navigate within one menu frame instead of 3. Finally, type-to-filter functionality has been added to the menus with greater than 10 values. This can initially be seen in the “More Modules” list as well as the “Grid Views” list.[asvc_before_after before_image=”76697″ after_image=”76695″]

Related Resources

Key Steps for a Successful UI Transition

Whether you’re implementing a brand new software solution or updating an existing solution, changes that affect the workflow of team members are often a major pain point for organizations. Taking steps to manage and communicate these changes and their benefits to your users can greatly reduce the friction faced during implementation and, in turn, increase adoption by users. As you prepare to transition to the new LabKey Server UI (being released as part of LabKey Server v17.3), we encourage you to take the following steps to help manage this change and help make the UI transition a success.

Test the Redesigned Interface

Test the new interface extensively in your staging and/or test environments. As part of the 17.2 release of LabKey Server, we included the “Core UI Migration” experimental feature that allows administrators to turn on the new UI. While the interface is still in active development and certain elements may shift slightly, the bulk of the navigation changes are represented, and we encourage administrators to explore the new UI and test for:

Changes to your primary user workflows (editors, readers, administrators, etc.)
Go through the workflows of your primary users; click through the available buttons and navigate through the interface as your user would, checking for changes to their standard workflows.

Broken customizations
Check to see that customizations you have made to the interface are still functioning as expected. As part of the UI redesign, we have refactored a good portion of our own CSS in order to make it easier to maintain the platform in the long run. As a result customizations made to your server’s CSS may need updating.

UI bugs that should be reported to LabKey
Reporting bugs that you encounter during testing is an important part of the redesign process. Your feedback helps us identify and prioritize fixes that need to be made to the interface.

Identifying updates that need to be made to your server customizations and changes to your user workflows early will give you the opportunity to make adjustments and prepare for any new-interface training that might need to be done with users.

Set a Go Live Date

Decide on a date that you will make the transition to the new UI. Make sure you account for adequate time to test the new version, communicate upcoming changes and your transition plan, and train users on the new UI.

Communicate Upcoming Changes and Transition Plan

Communicating upcoming changes and their implications for your users early and often is crucial to a smooth interface transition. When communicating details about the interface transition to users, make sure to include information about:

  • Transition timeline
  • Key benefits of the transition
  • Key changes/potential areas of frustration
  • How users can ask questions
  • How users can provide feedback

Provide User Training

Some of the changes being made to the LabKey Server interface during this redesign will affect how users perform certain tasks. If you discover through testing the interface in the context of your team’s key workflows that core tasks are affected by navigation changes, then providing training on how to accomplish this work in the new interface will help avoid frustration. For smaller changes, simply documenting the new process may be sufficient training, but in cases where a user’s workflow is significantly changed a training session may be more appropriate.

Answer Questions

Even with thorough testing, communication, and training, questions from your users are still inevitable. Develop and communicate how users can ask questions as they are are adjusting to the redesigned interface. Depending on the size of your team, that may mean communicating who the contact person is for questions, you may create a message board for questions and discussion, or you may host a handful of Q&A workshop sessions post-implementation. Whatever the method, making sure a user knows how they can have their questions answered will help prevent frustration when they encounter a change to their workflow.

Provide Feedback

Communicating feedback to the LabKey team is an essential part of the redesign process, and we are committed to making sure that you and your users have the best possible experience using LabKey Server. As you explore the redesigned interface in your test environment as an experimental feature, you can provide feedback using the “Give Feedback” button in the top right corner of the interface. You can also provide feedback directly to your LabKey account manager.

Related Resources

Genomics England and LabKey: Creating and securing “a dialogue between the clinical context and researchers.”

Genomics England 100,000 Genomes ProjectIn late 2015, Genomics England began working with LabKey to develop a LabKey Server-based data management and exploration portal that would facilitate the knowledge sharing dialogue between clinicians and researchers as part of the UK’s 100,000 Genomes Project.

The 100,000 Genomes Project, as characterized by Genomics England’s Chief Technology Officer, Jim Davies, is intended to promote “a dialogue between the clinical context and researchers.” This project, the largest national sequencing project of its kind in the world, will give both clinicians and researchers access to an unprecedented depth of data and information through the sequencing of 100,000 genomes from approximately 70,000 people including patients with a rare disease and their families, as well as patients with cancer. The mission of this dialogue is to ultimately bring benefit to patients and to enable new scientific discovery and medical insights in an ethical and transparent manner that will promote the development of a UK genomics industry.

The first phase of this collaboration centered around providing clinicians and researchers access to centralized phenotypic and sample information gathered from sites across the UK while ensuring security and privacy of patient information. The LabKey team focused development efforts during phase 1 on the aggregation, review, and integration of phenotype and genotype information from cancer and rare disease patient data.

This phase has provided:

  • Secure, extensible and reliable pipelines for data collection from 13 NHS Genomic Medicine Centres leading participant recruitment and partnering hospitals & clinics
  • Medical review workflow to assess data gathered of participants and families
  • Web portals for secure access of data
  • LabKey Server’s built-in reporting, querying, and visualization tools

LabKey and Genomics England are bringing the value of dialogue to the development process. LabKey is excited to continue its tradition of collaborating closely with its partners. With Genomics England, LabKey has developed a deep shared understanding of goals leading to a phased development roadmap of the LabKey Server platform. Close communication and collaboration will enable LabKey to flexibly accommodate new requirements and priority shifts to ensure a high-quality final product.

LabKey looks forward to the next phase of development of a “research” LabKey Server platform that will securely store and enable access to de-identified information that can be used by clinicians and researchers for advanced analysis. LabKey is proud to support Genomics England’s mission to promote a productive “dialogue” that will improve patient outcomes and scientific progress.

To learn more about the 100,000 Genomes Project, visit: https://www.genomicsengland.co.uk/the-100000-genomes-project/

Allen Institute for Cell Science Uses LabKey to Simplify Workflows and Accelerate Target Identification

LabKey partners at the Allen Institute for Cell Science are doing things a little differently. Launched in 2014 with a contribution from founder and philanthropist Paul G. Allen, the Institute was formed to integrate diverse technologies and approaches to study the cell as an integrated system. They are asking fundamental questions about cellular behavior to better understand healthy and pathological cells. Data and tools developed by the Institute are made publicly available to researchers around the world.

The Allen Institute for Cell Science team uses genome editing to add fluorescent markers to proteins in key cellular machinery and uses light microscopy to study the organization of that machinery and how it changes. During the generation of genome edited cell lines, they conduct quality control steps, including genotyping, stem cell marker analysis, karyotype testing, deep sequencing, and image-based assays. They also generate clonal lines for each gene and ensure that the cell line is useful for long term experiments. This work requires tracking cells, cell lines, genes, and all other quality control components through approximately 40 workflow steps.

The Allen Institute for Cell Science uses LabKey Server to capture metadata and assay data on each gene, cell, cell line, clone, and vector at each stage in the workflow: information that was previously housed in spreadsheets and raw data files. The Institute relies on the integrated views and query-ability of their LabKey managed data to efficiently identify target cells/cell lines to explore. Their use of LabKey Server also allows them to track the status of each entity as it makes its way through the processing pipeline, as well as monitor their complete workflow.

Allen Institute for Cell Science + LabKey Server Workflow

By centralizing their data, the Allen Institute for Cell Science will be able to accelerate their analysis and use insights gathered about their workflow to optimize their operations.

[vc_cta h2=”” shape=”square” style=”custom” custom_background=”#ededed”]Interested in using LabKey Server to optimize your workflow and accelerate data analysis?  Contact the LabKey team for more information![/vc_cta]

Next Generation Clinical Trial Transparency: Providing Management and Analysis of RNA Sequencing Data

LabKey has begun work with long-time partner the Immune Tolerance Network (ITN) to further clinical trial transparency by extending the LabKey Server platform to support management of RNA sequencing (RNA-Seq) and Next Gen Sequencing data. The ITN will be providing access to sequencing data, connecting raw data to downstream sequence analysis and visualizations that incorporate clinical data and other assay data through ITN’s research web portal, ITN TrialShare.

ITN TrialShare is an application built on the LabKey Server platform that supports both operational data management and post-publication sharing of data from clinical trials. ITN TrialShare was the first application of its kind to allow direct linking from major clinical trial publications to de-identified participant-level data and analyses.

As part of this new project, the LabKey team will provide custom development and configuration services to extend ITN TrialShare to support integration of and enhanced access to sequencing data. Improvements being explored as part of this project include:

  • Support for big data downloads such as FAST-Q and BAM raw data files
  • Integration with sequencing data transfer tools such as Globus Genomics
  • The addition of assay data filtering for RNA-Seq data, T-cell Repertoire, and WGS data
  • Support for Shiny in LabKey’s reporting framework, allowing real-time visualization of big data

[vc_cta h2=”” shape=”square” style=”custom” custom_background=”#ededed”]Interested in using LabKey Server to manage your research and help promote data transparency at your organization?  Contact the LabKey team for more information![/vc_cta]

About the Immune Tolerance Network

The Immune Tolerance Network (ITN) is a collaborative network for clinical research focused on the development of therapeutic approaches for asthma and allergy, autoimmune diseases, type 1 diabetes and solid organ transplantation that lead to immune tolerance. The ITN encompasses over 250 clinical sites and investigators and 14 core labs supporting 95 clinical trials (23 Allergy trials; 43 Autoimmunity trials; 29 Transplant trials). Read about LabKey and ITN’s partnership to develop ITN TrialShare >

LabKey to Provide Back End Data Storage and Analysis Portal for ResearchKit- and ResearchStack-based Apps

We are very excited to share that LabKey was recently selected to deliver a HIPAA and FISMA compliant data storage environment to support the collection of patient-provided data through a set of mobile device applications being developed by Boston Technology Corporation.

LabKey Server will serve as a centralized repository for data collected via the ResearchKit- and ResearchStack-based mobile applications and will integrate this data with related clinical information. The platform will also provide a portal for clinical partners to access and explore integrated data, conduct analysis, and share information with collaborators, using LabKey Server’s robust role-based permissions model and advanced security features to ensure HIPAA- and FISMA-compliant treatment of protected data.

The LabKey team is excited about this new project and the functionality it will bring to the LabKey Server platform, paving the way for future integrations with mobile research applications. This project will introduce the use of the LabKey Server platform as an enterprise-level back end service for applications developed with ResearchKit® and ResearchStack, and will allow us to offer this powerful technology to cutting-edge researchers who require rapid integration of patient-reported data with clinical data.[vc_cta h2=”” shape=”square” style=”flat”]Interested in using LabKey Server as a data management and analysis platform for your mobile app?
Contact the LabKey team to learn more!
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About Boston Technology Corporation

Boston Technology Corporation (BTC), a Boston-based digital health technology services company, provides mobile and web solution development for secure patient experience and engagement, medical and clinical research and IoT Human Interface applications. Please visit their case studies page for more information on applications developed by BTC for provider organizations, biotech and medical device companies, and major universities.[vc_column width=”1/4″][vc_single_image image=”76328″ img_size=”” onclick=”custom_link” link=”http://www.researchstack.org”][vc_column width=”3/4″]

About ResearchStack

ResearchStack is an SDK and UX framework for building research study apps on Android. It is designed from the ground up to meet the requirements of most scientific research, including capturing participant consent, extensible input tasks, and the security and privacy needs necessary for IRB approval.[vc_column width=”1/4″][vc_single_image image=”76327″ alignment=”center” onclick=”custom_link” link=”http://www.researchstack.org”][vc_column width=”3/4″]

About ResearchKit

ResearchKit is an open source framework introduced by Apple that allows researchers and developers to create powerful apps for medical research.[vc_column width=”1/4″]

LabKey Kicks Off Abstraction and NLP Pipeline Project for NCI SEER

In support of the National Cancer Institute (NCI) and the Department of Energy (DoE) initiative to use large-scale computing to influence cancer science, NCI’s Surveillance, Epidemiology, and End Results (SEER) Program has partnered with LabKey to develop an abstraction workflow and Natural Language Processing (NLP) pipeline that will automate the annotation and review of free-text pathology reports.

The NCI SEER Program works to provide information on cancer statistics in an effort to reduce the burden of cancer among the U.S. Population. SEER currently collects and publishes cancer incidence and survival data from population-based cancer registries covering approximately 30 percent of the U.S. population. The registries receive at least one unstructured pathology report on the more than 450,000 cases reported annually that are used in conjunction with other sources to abstract relevant information on the cases.

The initial version of the application will allow SEER to identify and select pathology reports of interest using a Linguamatics-based text-mining tool and make them available in a LabKey Server portal for manual annotation and abstraction of key elements. An annotation and task management pipeline will manage the stages of the abstraction, annotation, and review process, ensuring consistency by standardizing tasks and automating the workflow. To ensure the security of data being processed and generated, the application will utilize LabKey Server’s role-based security model and facilities that ensure regulatory compliance.

Future phases of development will introduce the use of Natural Language Processing engines to further accelerate the annotation process. Manually abstracted data from the initial phase of the project will be used by DoE laboratories to help develop and train NLP algorithms that will then be used to automate the abstraction of large numbers of pathology reports.


LabKey Server for Your Research

Interested in exploring LabKey Server as a bioinformatics solution for your organization? Contact us and the LabKey team will work with you to understand your needs and help determine if LabKey is the right fit for your research.

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Skyline User Group Presentation: Improved Quality Control Workflows and Other Panorama Updates

06082016-josh-asms-video-presentationDidn’t make it to this year’s Skyline User Group Meeting? Watch recorded sessions from the event, including Josh Eckels presentation on “Improved Quality Control Workflows and Other Panorama Updates.”

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Presentation Overview

Panorama is a web-based complement to Skyline, used by more than a hundred organizations to manage, analyze, and share targeted mass spec data generated by Skyline. Since being unveiled at ASMS 2015, Panorama’s support for QC workflows has expanded significantly. With input from the SProCoP team and the user community, new and improved metrics, automation, and visualizations build on the previous functionality. Additionally, Skyline and Panorama now include document version tracking for method building and other workflows, and Panorama now supports small molecule data. This presentation will demonstrate the new capabilities and outline plans for Panorama’s ongoing development.

About Josh

Josh Eckels has lead development on proteomics related projects for LabKey Server over the past 10+ years, and he currently oversees Panorama development. He is experienced in security-related projects, client-side end user applications, and server-side development. Prior to joining LabKey, Josh worked most recently on Amazon.com’s data warehouse, developing the software that schedules and executes loading and querying of more than 30 terabytes of data. Before that, he was the team lead for the debugger for BEA System’s WebLogic Workshop. At LabKey, he focuses on mass spectrometry, other assay types, experimental annotations and general infrastructure. Josh has a BS in Computer Engineering from Northwestern University.